Our lab has received NIH R21 funding to study osteocyte signaling within mineralized lacuna-canaliculi microenvironment.

• Post by: psoman
• April 25, 2021
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Public Health Relevance – Although it is largely accepted that osteocyte signaling plays a key role in a variety of bone diseases, evaluation of signaling propagation within the osteocyte network has been challenging due to their location within a calcified bone matrix. To that end, this work will develop a new model that not only replicates the in vivo like mineralized lacunar-canalicular structure and associated gradient of nutrient transport but also allows real-time study of signal propagation within an osteocyte network upon targeted mechanical stimulation.